2025-12-15 – Weekly Clinical Research News : Belmont vs. ICH E6: A historical sequence

Last week, our community engaged in some insightful discussions around foundational principles in clinical research. Members explored historical documents and their impact on current guidelines, debated ethical considerations, and shared best practices in patient recruitment. The dialogue was rich and informed, highlighting both the complexity and the evolution of the field.


This Week’s Hot Topics

Which came first: Belmont or ICH E6
There’s an intriguing thread unraveling the historical sequence and significance of these cornerstone documents. It’s a fascinating look at how foundational principles have shaped modern clinical research practices.
Read more here


Looking forward to another week of thought-provoking discussions. Feel free to dive into the ongoing conversations or start your own.

@AnitaR I keep a one-page Belmont→ICH E6 crosswalk in the site binder and, during consent, I tag the note like “respect for persons – ICH E6 4.8.10,” which reliably trims IRB questions on recruitment materials. It can feel heavy for minimal‑risk studies, but for multicountry trials it’s been a real time-saver.

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